Nspindle cell lesions of head and neck pdf

In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. The most common spindle cell lesion presenting along the uadt mucosa is spindle cell carcinoma spcc, which has many unique and challenging clinical and pathologic features. Although, undifferentiated tumors remain a challenge to the histopathologist, by describing the histological patterns and the subpatterns of the tumors, an attempt has been made for the diagnosis of the tumors and subsequently for implementation of. In the head and neck region, the two most important malignancies which can present with this appearance are spindle cell squamous carcinoma and malignant melanoma. It usually presents as a polypoid mass and often at an early stage due to local obstruc tive symptoms. Spindle cell carcinoma of the head and neck is a rare neoplasm. For biopsies from the head and neck assessment is further complicated by the range of tissues present at this site, and the limited amount of material which may be available for study.

Pdf spindle cell hemangioma hemangioendothelioma of. Some head and neck squamous cell carcinoma variants can be human papillomavirus hpvrelated and have improved outcomes. Sarcomatoid spindle cell carcinomas of the head and neck are unusual variants of squamous carcinoma commonly reported in the larynx but also described in other mucosal sites such as gingiva, tongue, hypopharynx and nasal cavity 1 2345678910111214151617. Immunohistochemistry ihc was performed on the representative paraffin blocks in 82 of the 103 cases. We at kyushu cancer center experienced 6 cases of spindle cell carcinoma which accounted for 0. Spindle epithelial tumor with thymuslike differentiation. Spindle epithelial tumor with thymuslike differentiation settle is a very rare thyroid tumor formally characterized by chan and rosai in 1991 as a tumor of the neck. The diagnosis of lesions with spindle cell morphology is often difficult. The most commond solid tumors to occur in this region are rhabdomyosarcoma, hodgkin disease, and nonhodgkin lymphoma. Two children are described who presented with signs and symptoms consistent with rhabdomyosarcoma, but who were found to hav e benign spindle cell lesions.

Of the total of 171 cases of mucosal spindle cell tumors of the head and neck, cases of sarcomatoid carcinoma were diagnosed and selected as per the diagnostic algorithm fig. Spindle cell carcinomas of the head and neck rarely harbor. Spindle cell carcinoma is an uncommon variant of squamous cell carcinoma characterized by spindled or pleomorphic cells which appear to be a true sarcoma but are actually epithelial. Spindle cell hemangioma sch, also known as spindle cell hemangioendothelioma, is a unique vascular tumor with combined microscopic features of both a cavernous hemangioma and kaposi sarcoma. Sarcomatoid spindle cell carcinoma of the head and neck. Spindle cell lesions can occur in head and neck skin, in the soft tissues of the scalp, orbit, and neck, and along the upper aerodigestive tract uadt mucosa. An algorithm for a systematic approach to their diagnosis is. Spindle cell carcinoma of the head and neck makes up 3% of all squamous carcinomas in the region and may occur at any site but is most common in the larynx. In this article, histological patterns and subpatterns of head and neck tumors are enlisted.